Re: Manipulating chromatin loops to regulate genes may offer future treatments for blood diseases(SGMO)
At least thousands.
For a start search pubmed.gov for zinc finger. 14,470,
Searching other journals and pub sources in foreign countries will produce just as many if not more. We will not see much published until there is a controling patent filed, in a huge majority of cases. This is true globally I am sure.
More important than defining the specific genes responsible for a disease in the method utilized to manipulate it or them. Supreme Court has found that genes cannot be patented.
One of these days EL et al are going to make it clear just how important and power their IP is.
Maybe this is the year. Possibilities,,,,,,let your imagination run wild, then think much much larger.
Kinda can give ya butterflies.
If it costs $300,000 per year to treat some hemo patients, and Shire/SGMO 'cure' only 100 per year = savings of $30 million each year.
"Cure' 1000 = $3 BILLION, per year. Nice savings for Medicaid and Medicare and insurance companies.
Cost of treatment, I assume the number is COP, estimated to be $30,000. plus mark up. $300 million per year? Nice for a rare disease. Well worth the price that Shire has agreed to. Now what are those other 3 monogenic diseases worth? Any ideas about those 17 rare monogenic diseases listed on the slide EL talks about that they are researching? And it was alluded that we would hear more about later in then year.
Do they have similar numbers? Is each worth as much as Hemo?
Dreaming? 17 times $300 million revs ( $45 million ) for SGMO.
17 X $1.5 BILLION. = $25.5 BILLION
I do not expect that all of these 'cures' will bring in this much money, but on average?
In the next five years I believe that we will also see some majorr diseases, "cured'. Cure just one form of Breast Cancer, what is that worth.
If they 'cure' one others will follow.
It has been over 12 years, Ed, I am ready for the big deal:)