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Msg  399455 of 546118  at  1/27/2010 5:25:41 PM  by

snugpharma


This Week in The New England Journal of Medicine (NEJM) - Alzheimer's Disease, Mechanisms of Disease

To the NEJM subscribers; Feel free to share the full article with us....snug


http://content.nejm.org/cgi/content/extract/362/4/329

Previous Volume 362:329-344 January 28, 2010 Number 4
Next

REVIEW ARTICLE
MECHANISMS OF DISEASE

Alzheimer's Disease

Henry W. Querfurth, M.D., Ph.D., and Frank M. LaFerla, Ph.D.

Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.




More than 35 million people worldwide 5.5 million in the United States have Alzheimer's disease, a deterioration of memory and other cognitive domains that leads to death within 3 to 9 years after diagnosis. Alzheimer's disease is the most common form of dementia, accounting for 50 to 56% of cases at autopsy and in clinical series. Alzheimer's disease combined with intracerebral vascular disease accounts for another 13 to 17% of cases.

The principal risk factor for Alzheimer's disease is age. The incidence of the disease doubles every 5 years after 65 years of age, with the diagnosis of . . . [Full Text of this Article]

Protein Abnormalities in Alzheimer's Disease

β-Amyloid

Tau

The Synapse in Alzheimer's Disease

Synaptic Failure

Depletion of Neurotrophin and Neurotransmitters

Mitochondrial Dysfunction

Oxidative Stress

Insulin-Signaling Pathway

Vascular Effects

Inflammation

Calcium

Axonal-Transport Deficits

Aberrant Cell-Cycle Reentry

Cholesterol Metabolism

Conclusions


Source Information

From the Department of Neurology, Caritas St. Elizabeth's Medical Center, Brighton, MA (H.W.Q.); the Department of Neurology, Tufts Medical Center, Boston (H.W.Q.); the Department of Neurology, Rhode Island Hospital and the Warren Alpert Medical School at Brown University, Providence (H.W.Q.); and the Department of Neurobiology and Behavior, University of California, Irvine, Irvine (F.M.L.).

Address reprint requests to Dr. Querfurth at the Department of Neurology, Rhode Island Hospital, 563 Eddy St., Providence, RI 02903-4923, or at henry_querfurth@brown.edu.





 
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399486 FULL ARTICLE....: This Week in The New England Journal of Medicine (NEJM) - Alzheimer's Disease, Mechanisms of Disease masterlongevity 14 1/27/2010 9:47:00 PM


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